Ricerc@Sapienza

Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains aclosed, humid, sterile and isolated environment. Wound infection is considered arelative contraindication. The objective of this study is to extend the indications forVAC therapy to include infected wounds by demonstrating its ability to increase theantibiotic concentration in the damaged and infected tissues. Patients who presentedwith ulcers infected with daptomycin-sensitive bacteria were eligible to be enrolledin this prospective study.

OBJECTIVE: A wound is defined as chronic when it requires more than 6 weeks to heal. The link between chronic wounds and depression was first pointed out by House and Hughes in 1996 and later evaluated by other numerous studies. Several studies demonstrate that among chronic skin wounds causing chronical physical disease, the leg ulcers are the most frequently associated with depression. The aim of our study is to evaluate the prevalence of depression in patients with different types of chronic wounds.