cigarette smoke

Proprietà chemiopreventive e chemiosensibilizzanti dei sesquiterpeni cariofillanici

Proprietà chemiopreventive e chemiosensibilizzanti dei sesquiterpeni cariofillanici

Il gruppo di ricerca studia il ruolo del β-cariofillene e del suo metabolita β-cariofillene ossido come composti naturali, della famiglia dei composti cariofillanici, ad attività chemiosensibilizzante, chemiopreventiva e citoprotettiva. Il lavoro è svolto mediante approcci farmacologici e tossicologici su modelli cellulari tumorali e non tumorali, con lo scopo di chiarire i meccanismi d’azione alla base degli effetti osservati.

Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants

Extracellular vesicles (EVs) have emerged as key regulators of cell-cell communication during inflammatory responses to lung injury induced by diverse pulmonary toxicants including cigarette smoke, air pollutants, hyperoxia, acids, and endotoxin. Many lung cell types, including epithelial cells and endothelial cells, as well as infiltrating macrophages generate EVs. EVs appear to function by transporting cargo to recipient cells that, in most instances, promote their inflammatory activity.

Relationship between domestic smoking and metals and rare earth elements concentration in indoor PM2.5

Cigarette smoke is the main source of indoor chemical and toxic elements. Cadmium (Cd), Thallium (Tl), Lead (Pb) and Antimony (Sb) are important contributors to smoke-related health risks. Data on the association between Rare Earth Elements (REE) Cerium (Ce) and Lanthanum (La) and domestic smoking are scanty. To evaluate the relationship between cigarette smoke, indoor levels of PM 2.5 and heavy metals, 73 children were investigated by parental questionnaire and skin prick tests.

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