Anti-Candida albicans biofilm activity of extracts from two selected indigenous Algerian plants. Clematis flammula and Fraxinus angustifolia
Candida albicans biofilm is associated with high rates of morbidity and resistance to antifungals. The aim of the present study is to evaluate the anti-Candida albicans biofilm activity of some indigenous Algerian medicinal plant extracts: Clematis flammula and Fraxinus angustifolia and their influence on the virulence factors of C. albicans. The anti-biofilm activity was determined using crystal violet assay while the cell surface hydrophobicity (CSH) was estimated in a water-hydrocarbon two-phase assay. Moreover, germ tube formation and hyphae elongation were assessed microscopically. F.