It now belongs to common sense, as well as to administrative law, the concept of legacy that within the cultural heritage is both the object and the matrix of a particular form of design that tends to protect or restore in the physical space new or lost qualitiesover time.
Background: Multiple sclerosis has an extremely variable natural course. In most patients, disease starts with a relapsing-remitting (RR) phase, which proceeds to a secondary progressive (SP) form. The duration of the RR phase is hard to predict, and to date predictions on the rate of disease progression remain suboptimal. This limits the opportunity to tailor therapy on an individual patient's prognosis, in spite of the choice of several therapeutic options.
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