cross-over studies

Clinical outcomes of experimental gingivitis and peri-implant mucositis treatment with professionally administered plaque removal and photodynamic therapy

Aim: To comparatively evaluate the outcomes of professionally administered plaque removal (PAPR) and photodynamic therapy (PDT) in the treatment for experimentally induced gingivitis (G) and peri-implant mucositis (p-iM). Materials and methods: Twenty systemically healthy patients, each contributing a single implant-supported unit in a posterior sextant and a tooth within the same quadrant, were selected. Patients underwent an experimental G and p-iM trial consisting of a 2-week period of undisturbed plaque accumulation and a 6-week resolution phase following treatment administration.

Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers.

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