?-Caryophyllene oxide as a new chemosensitizing agent to enhance sorafenib efficacy in liver cancer chemotherapy.
We have investigated the ability of ?-caryophyllene oxide (CRYO), a naturally occurring sesquiterpene component of many essential oils, to inhibit, at non-
toxic doses, ABC pumps and improve the response of HCC cells to sorafenib. CRYO was able to induce chemosensitization of liver cancer cells to sorafenib by favoring its intracellular accumulation.