Ricerc@Sapienza

The most prevalent malignancy in the oral cavity is represented by oral
squamous cell carcinoma, an aggressive disease mostly detected in low‐income
communities. This neoplasia is mostly diffused in older men particularly
exposed to risk factors such as tobacco, alcohol, and a diet rich in fatty foods
and poor in vegetables. In oral squamous cell carcinoma, a wide range of
matrix‐cleaving proteinases are involved in extracellular matrix remodeling of
cancer microenvironment. In particular, matrix metalloproteinases (MMPs)

Huntington's disease (HD) has traditionally been described as a disorder purely of the brain, however evidence indicates that peripheral abnormalities are also commonly seen. Among others, severe unintended body weight loss represents a prevalent and often debilitating feature of HD pathology, with no therapies available. It correlates with disease progression and significantly affects the quality of life of HD patients.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that maintains the cell's redox balance state and reduces inflammation in different adverse stresses. Under the oxidative stress, Nrf2 is separated from Kelch-like ECH-associated protein 1 (Keap1), which is a key sensor of oxidative stress, translocated to the nucleus, interacts with the antioxidant response element (ARE) in the target gene, and then activates the transcriptional pathway to ameliorate the cellular redox condition.

Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO-CU-PEG coatings can reduce fungal adhesion, proliferation and biofilm formation.

Nutraceuticals represent complementary or alternative beneficial products to the expensive and high-tech therapeutic tools in modern medicine. Nowadays, their medical or health benefits in preventing or treating different types of diseases is widely accepted, due to fewer side effects than synthetic drugs, improved bioavailability and long half-life. Among herbal and natural compounds, curcumin is a very attractive herbal supplement considering its multipurpose properties.

OBJECTIVE:The aim of this study is to assess the efficacy of orally administered combination of hyaluronic acid (HA), chondroitin sulfate (CS), curcumin, and quercetin for the prevention of postcoital recurrent urinary tract infection (UTI) in reproductive age women.

Cancer is a multi-factorial disease and is a major cause of morbidity and mortality worldwide. Dietary phytochemicals have been used for the treatment of cancer throughout history due to their safety, low
toxicity, and general availability. Several studies have been performed to elucidate the effects of dietary phytochemicals on cancer metabolism, and many molecular targets of phytochemicals have been

In this work we used a combination of different techniques to investigate the adsorption properties of curcumin by zeolite type A for potential use as an anticancer drug carrier. Curcumin is a natural water-insoluble drug that has attracted great attention in recent years due to its potential anticancer effect in suppressing many types of cancers, while showing a synergistic antitumor effect with other anticancer agents. However, curcumin is poorly soluble in aqueous solutions leading to the application of high drug dosage in oral formulations.

In this work, a combination of different techniques has been used to assess the potential
use of zeolite nanoporous materials for the delivery of natural bioactive curcumin.
Curcumin is a water-insoluble drug extracted from turmeric (Curcuma longa) plant. In
recent years, the potential anticancer effect of curcumin in suppressing many types of
cancers, while showing a synergistic antitumor effect with other anticancer agents, has
attracted great attention. However, the poorly soluble formulation of curcumin is a

The ability of synthetic zeolites to encapsulate and deliver the bioactive compound curcumin, which is well-known for its therapeutic effects, is investigated. Curcumin, the active ingredient of turmeric, is a water-insoluble compound that has attracted great attention in recent years because of its anti-inflammatory properties and anticancer activity. In our research, we use different types of zeolites (LTA and FAU) for loading of curcumin.