Ricerc@Sapienza

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is responsible
for coronavirus disease 2019 (COVID-19), which has rapidly spread across the world, becoming
a pandemic. The “cytokine storm” (CS) in COVID-19 leads to the worst stage of illness, and its timely
control through immunomodulators, corticosteroids, and cytokine antagonists may be the key to
reducing mortality. After reviewing published studies, we proposed a Cytokine Storm Score (CSs) to

In March 2020, the World Health Organization declared the severe acute respiratory syndrome corona virus 2 (SARS-CoV2) infection to be a pandemic disease. SARS-CoV2 was first identified in China and, despite the restrictive measures adopted, the epidemic has spread globally, becoming a pandemic in a very short time. Though there is growing knowledge of the SARS-CoV2 infection and its clinical manifestations, an effective cure to limit its acute symptoms and its severe complications has not yet been found.

A pandemic outbreak of COVID-19 has been sweeping the world since December. It begins as a respiratory infection that, mainly in men with diabetes or renal impairment, evolves into a systemic disease, with SARDS, progressive endothelial cell damage, abnormal clotting and impaired cardiovascular and liver function. Some clinical trials are testing biological drugs to limit the immune system dysregulation, "cytokines storm", that causes the systemic complications of COVID-19.