X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics
Exposure of the developing or adult brain to ionizing radiation (IR) can cause cognitive impairment and/
or brain cancer, by targeting neural stem/progenitor cells (NSPCs). IR effects on NSPCs include transient
cell cycle arrest, permanent cell cycle exit/differentiation, or cell death, depending on the experimental
conditions. In vivo studies suggest that brain age influences NSPC response to IR, but whether this is
due to intrinsic NSPC changes or to niche environment modifications remains unclear. Here, we describe