Indolylarylsulfones as novel potent anti-HIV-1 agents
Acquired Immune Deficiency Syndrome (AIDS) is a leading cause of death worldwide. HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key highly active antiretroviral therapy drugs in the clinical management of AIDS/HIV-1 infections.
Our recent studies showed that indolylarylsulfones (IASs) bearing a cyclic moiety on the 2-carboxamide nitrogen, linked through a short spacer group,are endowed with potent antiretroviral activity.[1]