Ricerc@Sapienza

The gut microbiota is now considered as a symbiotic organ playing an important role in human health and disease
development and has been recently recognized as a modulator of drug metabolism and toxicity. Here, we briefly
discuss new findings describing how the gut microbiota is now considered to be a central player in drug metabolism
and personalized medicine.

para-Methyl-4-methylaminorex (4,4’-DMAR) is a synthetic, substituted oxazoline derivative and analogue of the scheduled aminorex and 4-methylaminorex (4-MAR), both of which originally designed and synthesized as appetite suppressants. The psychostimulant properties of these substances are due to the interaction with dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET).