Possible Correlation between Cholinergic System Alterations and Neuro/Inflammation in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central
nervous system. Although the etiology of MS is still unknown, both genetic and environmental
factors contribute to the pathogenesis of the disease. Acetylcholine participates in the modulation
of central and peripheral inflammation. The cells of the immune system, as well as microglia,
astrocytes and oligodendrocytes express cholinergic markers and receptors of muscarinic and