Ricerc@Sapienza

In this paper, a new model describing the human immunodeficiency virus (HIV)-acquired immuno deficiency syndrome (AIDS) epidemic spread is proposed. The improvement with respect to the known models has been driven by recent results obtained from historical data collection and the suggestions given by the World Health Organization: the characteristics of the virus diffusion, mainly by body fluids, imply the trivial fact that wise behaviors of healthy subjects and fast timely recognition of a new positive diagnosis should reduce the spread quite fast.

A fully robotized polishing of metallic surfaces may be insufficient in case of parts with complex geometric shapes, where a manual intervention is still preferable. Within the EU SYMPLEXITY project, we are considering tasks where manual polishing operations are performed in strict physical Human-Robot Collaboration (HRC) between a robot holding the part and a human operator equipped with an abrasive tool. During the polishing task, the robot should firmly keep the workpiece in a prescribed sequence of poses, by monitoring and resisting to the external forces applied by the operator.

The world of machine-to-machine (M2M) communication is gradually moving from vertical single purpose solutions to multi-purpose and collaborative applications interacting across industry verticals, organizations and people - A world of Internet of Things (IoT). The dominant approach for delivering IoT applications relies on the development of cloud-based IoT platforms that collect all the data generated by the sensing elements and centrally process the information to create real business value.

Placing the needle inside the epidural space for locoregional anesthesia is a challenging procedure, which even today is left to the expertise of the operator. Recently, we have demonstrated that the use of optically sensorized needles significantly improves the effectiveness of this procedure. Here, we propose an optimized configuration, where the optical fiber strain sensor is directly integrated inside the epidural catheter. The new design allows the solving of the biocompatibility issues and increases the versatility of the former configuration.

A biosensor platform based on Bloch Surface Waves and operating in angular interrogation mode is applied to the detection of a clinical biomarker (HER2-neu/ERBB2) related to breast cancer initiation/progression. Preparing regions for specific recognition of different proteins as well as a reference on the biochip enables to correct the signal for nonspecific effects. Additionally, label-free analysis and surface wave enhanced fluorescence detection can be applied and compared directly on the platform. Cell lysates with high and low expression levels of ERBB2 are analyzed.

We report on the detection of an angiogenic molecule Vascular Endothelial Growth Factor (VEGF) in different biological matrices by means of a new integrated biosensing platform exploiting the properties of Bloch surface waves. The new platform takes advantage of a tandem configuration, in which both label-free and enhanced fluorescence detection are implemented. Specifically designed one dimensional photonic crystals were deposited directly on disposable and low cost plastic biochips.

This paper shows a detailed analysis of the semiconductor-to-metal transition (SMT) in a vanadium dioxide (VO2) film deposited on silicon wafer. The vanadium dioxide phase transition is studied in the wide mid-infrared range 2-12 μm, by analyzing the transmittance and the reflectance measurements, and the calculated emissivity from the sample. The temperature behavior of the emissivity during the SMT put into evidence the phenomenon of the anomalous absorption in vanadium dioxide which has been explained by applying the Maxwell Garnett effective medium approximation theory.

We investigated a metamaterial composed by silicon carbide (SiC) subwavelength oriented wires, onto silicon substrate in the mid- to long- infrared range. A simple but versatile method was developed and implemented, combining homogenization techniques with the transfer matrix method for birefringent layered materials to model an effective medium layer where different inclusions content (filling factor) as well as different shape and orientation of inclusions (depolarization factors) are taken into account.

Particle Therapy (PT) is a radiation therapy technique in which solid tumors are treated with charged ions and exploits the achievable highly localized dose delivery, allowing to spare healthy tissues and organs at risk. The development of a range monitoring technique to be used on-line, during the treatment, capable to reach millimetric precision is considered one of the important steps towards an optimization of the PT efficacy and of the treatment quality.

Scintillation mechanisms in gases offer the possibility of an optical readout of micropattern gas detectors. This approach takes advantage of the large progress achieved in last years in the performance of the photosensors, opening the way to the realization of high granularity and very sensitive particle trackers. In this paper, the features of a triple-GEM structure filled with a He/CF4 (60/40) mixture and readout by a CMOS sensor are described.