Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system
Diabetes induces early sufferance in the cholinergic septo-hippocampal system, characterized by
deficits in learning andmemory, reduced hippocampal plasticity and abnormal pro-nerve growth factor
(proNGF) release from hippocampal cells, all linked to dysfunctions in the muscarinic cholinergic
modulation of hippocampal physiology. These alterations are associated with dysregulation of several
cholinergic markers, such as the NGF receptor system and the acetylcholine biosynthetic enzyme