The development of the human uterus: morphogenesis to menarche
There is emerging evidence that early uterine development in humans is an important determinant of conditions such as ontogenetic progesterone resistance, menstrual preconditioning, defective deep placentation and pre-eclampsia in young adolescents. A keyobservation is the relative infrequency of neonatal uterine bleeding and hormone withdrawal at birth. The origin of the uterus from the fusion of the two paramesonephric, or Mu¨llerian, ducts was described almost 200 years ago. The uterus forms around the 10th week of foetal life.