Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement
Cigarette smoking is a recognized risk factor for colon cancer and nicotine, the
principal active component of tobacco, plays a pivotal role in increasing colon cancer
cell growth and survival. The aim of this study was to determine the effect of
nicotine on cellular Caco-2 and HCT-8 migration and invasion, focusing on epithelial
to mesenchymal transition (EMT) induction, and COX-2 pathway involvement. In
both these cell lines, treatment with nicotine increased COX-2 expression and the