epigenetic modification

Epigenetics of cellular differentiation and tumorigenesis

Epigenetics of cellular differentiation and tumorigenesis

The research group focuses on epigenetics as a central driver of cellular differentiation and tumor development, with particular emphasis on hematologic malignancies. The research explores how epigenetic programs—based on DNA methylation, histone modifications, and non-coding RNA regulation—shape cell identity, plasticity, and, when disrupted, predisposition to malignancy. A major line of investigation examines how the epigenome governs hematopoietic maturation.

The inter-Talk between Mycobacterium tuberculosis and the epigenetic mechanisms

Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history.

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