The effect of standard versus longer intestinal bypass on glp-1 regulation and glucose metabolism in patients with type 2 diabetes undergoing roux-en-y gastric bypass. The long-limb study
OBJECTIVE Roux-en-Y gastric bypass (RYGB) characteristically enhances postprandial levels of glucagon-like peptide 1 (GLP-1), a mechanism that contributes to its profound glucose-lowering effects. This enhancement is thought to be triggered by bypass of food to the distal small intestine with higher densities of neuroendocrine L-cells.