Ricerc@Sapienza

This study shows that urinary metabolic profiling is able to find significant differences between HC, AD and SUDD. In particular, it interesting to note that the only two metabolites that significantly differed between two of the three groups, namely hippurate and methanol, seem to have a profiling opposite than in IBD. Why this occurs is unknown, but it clearly identifies a different metabolic profile not only when compared with healthy people, but also when compared with other inflammatory intestinal conditions, such as IBD.

Covered self-expandable metal stents might represent a valid adjunctive to arrest hemorrhage in patients with obstructing, bleeding colorectal cancer, in whom the usual techniques have failed.
In our center, in the last 16 years more than 160 patients were treated with self-expandable metal stents to relieve malignant colorectal obstruction.
Eight patients with malignant colorectal obstruction had placement of a covered self-expandable metal stent to arrest a residual hemorrhage, after treatment with Argon laser.

importanza di criteri selettivi nell'applicare lo stent colorettale in condizioni di emergenza

OBJECTIVE:

The aim of the study was to systematically review the diagnostic utility of serum biomarkers for the diagnosis of necrotizing enterocolitis (NEC).
METHODS:

We conducted an electronic and manual search of the available evidence. We included studies reporting data on the diagnostic accuracy of "serum" biomarkers for the diagnosis of NEC, available until January 2016.
RESULTS:

BACKGROUND AND AIMS:
Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase the risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates of malignancy and HLH in pediatric patients with IBD exposed to infliximab (IFX) with patients not exposed to biologics and calculated standardized incidence ratios (SIRs).

BACKGROUND:
The revised Porto criteria identify subtypes of paediatric inflammatory bowel diseases: ulcerative colitis [UC], atypical UC, inflammatory bowel disease unclassified [IBDU], and Crohn's disease [CD]. Others have proposed another subclassifiction of Crohn's colitis. In continuation of the Porto criteria, we aimed to derive and validate criteria, termed "PIBD-classes," for standardising the classification of the different IBD subtypes.

No abstract available

tBackground: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 3 (RIP3) and mixed lineage kinase domain-like protein (MLKL).Aims: The aim of this study is to examine in depth in vitro and ex vivo the contribution of necroptosis tointestinal inflammation.Methods: In vitro: we used an intestinal cell line, HCT116RIP3, produced in our laboratory and overex-pressing RIP3.

Background: Pancreatic ductal adenocarcinoma (PDAC) early diagnosis is crucial and new, cheap and user-friendly techniques for biomarker identification are needed. “Protein corona” (PC) is emerging a new bio-interface potentially useful in tumor early diagnosis. In a previous investigation, we showed that relevant differences between the protein patterns of PCs formed on lipid NPs after exposure to PDAC and non-cancer plasma samples exist. To extend that research, We performed this pilot study to investigate the effect of PDAC tumor size and distant metastases on PC composition.

BACKGROUND & AIMS: Metformin seems to have anticancer effects. However, it is not clear whether use of glycemia and metformin affect outcomes of patients with advanced
pancreatic neuroendocrine tumors (pNETs). We investigated the association between glycemia and progression-free survival (PFS) of patients with pNETs treated with everolimus
and/or somatostatin analogues, as well as the association between metformin use and PFS time. METHODS: We performed a retrospective analysis of 445 patients with advanced