Ricerc@Sapienza

Abstract: Background: In recent years, proton pump inhibitors (PPIs) have been investigated at high-dose
tomodulate tumormicroenvironment acidification thus restoring chemotherapeutic sensitivity. This is the
first trial to study activity and safety of repurposing high dose rabeprazole combined with metronomic
capecitabine (mCAP). Methods: A phase II study in which patients with gastrointestinal cancer,
refractory to standard treatments, who had a life expectancy >3 months, were blind randomized

No abstract available

COVID-19 pandemic enforced the interruption of routine endoscopic examinations raising the issue of potential delays in the diagnosis of high-risk lesions. We conducted a multicentre study to assess the decrease of GI and pancreato-biliary high-risk lesions detection consequent to the reduction of the endoscopic activity. The lockdown period was compared to the equivalent timeframe of the previous 3 years.