Evaluating mtDNA patterns of genetic isolation using a re-sampling procedure: A case study on Italian populations
ACKGROUND:
A number of studies which have investigated isolation patterns in human populations rely on the analysis of intra- and inter-population genetic statistics of mtDNA polymorphisms. However, this approach makes it difficult to differentiate between the effects of long-term genetic isolation and the random fluctuations of statistics due to reduced sample size.
AIM:
To overcome the confounding effect of sample size when detecting signatures of genetic isolation.
SUBJECTS AND METHODS: