Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release.
This work proposes a unified framework to leveragebiological information in network propagation-based gene prior-itization algorithms. Preliminary results on breast cancer datashow significant improvements over state-of-the-art baselines,such as the prioritization of genes that are not identified aspotential candidates by interactome-based algorithms, but thatappear to be involved in/or potentially related to breast cancer,according to a functional analysis based on recent literature.
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