Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery
Graphene oxide (GO) is a single-atomic-layered material made of a sheet of oxidized carbon atoms arranged in a honeycomb structure. Thanks to the notable physical and chemical properties of GO, GO-based nanomaterials have applications in many fields of research, including gene delivery. It has been reported that pristine GO can absorb single-stranded DNA and RNA through ?-? stacking, which cannot be used as a gene carrier because it is hard to load double-stranded DNA (dsDNA).