glial cells

Cellular Neurophysiology and Neuromuscular Disorders

Cellular Neurophysiology and Neuromuscular Disorders

The research group focuses its activity on an in-depth exploration of the cellular and molecular mechanisms governing the development, plasticity, aging, and pathophysiology of the nervous system. Particular attention is devoted to Duchenne Muscular Dystrophy, a condition traditionally considered muscular but now recognized for its significant implications on both the central and peripheral nervous systems, with consequences for neurodevelopment, cognitive functions, and multiple neurobiological processes.

Functional Characterization of Muscarinic Receptors in Human Schwann Cells

Functional characterization of muscarinic cholinergic receptors in myelinating glial cells has been well described both in central and peripheral nervous system. Rat Schwann cells (SCs) express different muscarinic receptor subtypes with the prevalence of the M2 subtype. The selective stimulation of this receptor subtype inhibits SC proliferation, improving their differentiation towards myelinating phenotype.

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