Ricerc@Sapienza

Background/aims: Hepatitis C virus (HCV) has been identified in tubular epithelial cells of infected patients, however the presence of tubular dysfunction, which is a risk factor for chronic kidney disease, has never been examined in vivo. The present prospective longitudinal study aimed to estimate the prevalence of tubular dysfunction alone or with glomerular damage and its evolution after HCV clearance in cirrhotic patients.

Background: Hepatitis C virus (HCV) infection is associated with an increased risk of renal disease. The correlation between HCV and glomerular damage is well recognized, but limited data are available on HCV-mediated tubular damage. Recently, several novel direct antiviral agents (DAAs) have been approved for HCV treat- ment, but the effects of HCV clearance on renal involvement (RI) has not been fully characterized.