Ricerc@Sapienza

The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques.

The theme of designing in historic contexts is as old as the history of human construction. It could be said that every construction is a redesign of something pre-existing, whether artificial or natural. Since antiquity, the act of rewriting atop an existing building is determined, beyond merely functional aspects, by the desire to mark a gap, an interruption in a pre-existing condition. This occurs through the strong, and in some cases even violent, introduction of something new; an act that also comports a re-semantization of the building to be modified.