Ricerc@Sapienza

Nelle macromolecole biologiche possono verificarsi cambiamenti dello stato di aggregazione controllati dalla combinazione con piccole molecole.

Anemia is a highly prevalent comorbidity in heart failure (HF) patients and represents both a marker of HF severity and a predictor of poor prognosis.
Anemia is per se associated with impaired exercise performance and functional capacity.
Iron deficiency (ID) is an important comorbidity of HF, but the diagnosis and correction of ID remainlargely unrecognized in the cardiology community.

An optoelectronic, integrated system-on-glass for on-chip detection of biomolecules is here presented. The system’s working principle is based on the interaction, detected by a hydrogenated amorphous silicon photosensor, between a monochromatic light travelling in a SU-8 polymer optical waveguide and the biological solution under analysis. Optical simulations of the waveguide coupling to the thin-film photodiode with a specific design were carried out.

An ultra-compact plasmonics-based sensor is investigated which is excited by Fano resonance. The structure is numerically simulated by the finite-difference time-domain method. The sensor utilizes unique waveguide geometry named as metal-insulator-metal (MIM) waveguide geometry which has an intriguing feature to confine signal far beyond diffraction light. Thus, it is used to devise ultra-compact optical circuits. The MIM waveguide is coupled to a pair of elliptical ring resonators and the interaction between the resonators excites special mode which is known as Fano resonance mode.