Ricerc@Sapienza

Emicizumab has been approved in several countries for regular prophylaxis in patients with congenital haemophilia A and FVIII inhibitors because it substantially reduces their bleeding risk and improves quality of life. However, although significantly less frequent, some breakthrough bleeds may still occur while on emicizumab, requiring treatment with bypassing or other haemostatic agents. Thrombotic complications have been reported with the associated use of activated prothrombin complex concentrates.

Introduction: In case of malignant cerebral infarction and progressive neurological
worsening, decompressive craniectomy is the surgical option that is recommended
when medical therapies fail. The occurrence of an intracerebral hemorrhage after
reconstruction of the bone defect is extremely rare. This is an extremely rare
complication, with only four cases reported thus far in the literature.
Case Report: A 54-year-old male suffered a malignant cerebral infarction and
progressive neurological worsening requiring decompressive hemicraniectomy. Three

Expulsion leiomyoma can represent an emergency condition and may lead to severe vaginal hemorrhage with anemia and urgent hysterectomy. Among medical treatments used for leiomyoma, Selective progesterone receptor modulators (SPRM) and, in particular, Ulipristal Acetate (UPA) have been proved to be effective in the management of bleeding and myoma size reduction. However, to our knowledge, there are no cases reported in literature on the use of UPA used as ‘emergency’ medical therapy in patients with severe anemia and vaginal bleeding due to expulsion leiomyoma.

Background: A wide variety of hemostats are available as adjunctive measures to improve hemostasis during surgical procedures if residual bleeding persists despite correct application of conventional methods for hemorrhage control. Some are considered active agents, since they contain fibrinogen and thrombin and actively participate at the end of the coagulation cascade to form a fibrin clot, whereas others to be effective require an intact coagulation system.