Diversity of monopolar and bipolar nanosecond pulsed electric signals on the metallo-enzyme superoxide dismutase (SOD), a modelling approach
Recent papers showed that when dealing with nanosecond pulsed electric fields (nsPEFs), bipolar pulses proved far less effective at membrane permeabilization and at cell killing than monopolar ones, contrary to what happens in the microsecond range. The mechanism at the basis of such selective response of cells is not fully elucidated. One hypothesis worthwhile to test could be a direct action of nsPEFs on intracellular enzyme reactions.