A novel role for Nhp6 proteins in histone gene regulation in Saccharomyces cerevisiae
Maintaining a stable and balanced histone pool is of paramount importance for genome stability and fineregulation of DNA replication and transcription. This involves a complex regulatory machinery, exploitingtranscription factors as well as histone chaperones, chromatin remodelers and modifiers. The functionaldetails of this machinery are as yet unclear. Previous studies report histone decrease in mammalianand yeast HMGB family mutants. In this study we find that Nhp6 proteins, the S.