Pediatric high-grade glioma: a heterogeneous group of neoplasms with different molecular drivers
High-grade gliomas(HGGs) in pediatric age have the same bad prognosis as those arising in adults. Approximately one-half of HGGs in children
occur in the brain stem, most frequently within the pons as diffuse intrinsic pontine glioma or other midline structures. Although they have the
same histological appearance of adult malignant gliomas, in recent years, the extensive use of molecular profiling techniques has demonstrated
significant molecular differences between the two age groups. These data have led to a major reclassification of pediatric HGG (pHGG) based