Myogenic oxidative imbalance interferes with antral motility in obese subjects
Background: Obesity is characterized by a systemic low-grade chronic inflammatory oxidative condition that affects vascular and cardiac smooth muscle relaxation. In human antrum, relaxation is mediated
by vasoactive intestinal peptide (VIP) through cAMP and cGMP signaling pathways. A genome-wide association study has demonstrated an association between VIP and obesity.
Aim: To evaluate smooth muscle activity in human obese antrum, both in in vitro preparations as well as in vivo.