Characterization of the novel HLA-DQA1*01:49 allele by sequencing-based typing
HLA-DQA1*01:49 differs from HLA-DQA1*01:01:01:06 by one nucleotide substitution in codon 9 in exon 2.
human leukocyte antigen
The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position
The HLA-B*27 peptidome has drawn significant attention due to the genetic association between some of the HLA-B*27 alleles and the inflammatory rheumatic disease Ankylosing Spondylitis (AS), for which a comprehensive biological explanation is still lacking. This study aims to expand the known limits of the HLA-B*27 peptidome to facilitate selection and testing of new peptides, possibly involved in the disease.