Halting hyaluronidase activity with hyaluronan-based nanohydrogels: development of versatile injectable formulations
Hyaluronan (HA) is among the most used biopolymers for viscosupplementation and dermo-cosmetic applications. However, the current injectable HA-based formulations present relevant limitations: I) unmodified HA is quickly degraded by endogenous hyaluronidases (HAase), resulting in short lasting properties; II) cross-linked HA, although shows enhanced stability against HAase, often contains toxic chemical cross-linkers.