Taming axial dispersion in hydrodynamic chromatography columns through wall patterning
A well-known limitation of hydrodynamic chromatography arises from the synergistic interaction
between transverse diffusion and streamwise convection, which enhances axial dispersion through
the Taylor-Aris mechanism. We show that a periodic sequence of slip/no-slip conditions at the channel
walls (e.g., representing wall indentations hosting stable air pockets) can significantly reduce axial
dispersion, thus enhancing separation performance. The theoretical/numerical analysis is based on a