Ricerc@Sapienza

Introduction: Vitamin D is a fat-soluble hormone with
pleiotropic effects, whose deficiency in the elderly
contributes to the development of osteoporosis
and sarcopenia, increasing the risk of fractures, falls
and consequent morbidity and mortality. Studies
show a very low level of vitamin D in patients with
hip fractures but it has never been shown whether
there is an influence of inflammatory stress linked
to surgery in reducing these levels or whether it is
linked only to pre-fracture conditions.

Obesity and type 2 diabetes have both rapidly increased during the last decades and are continuing to increase at an alarming rate worldwide. Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes.