NK cell reconstitution in paediatric leukemic patients after T-cell-depleted HLA-haploidentical haematopoietic stem cell transplantation followed by the reinfusion of iCasp9-modified donor T cells
-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve immune reconstitution and represents an interesting strategy to enhance the success of haplo-HSCT.