Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation
Extracellular vesicles (EVs) are released by different cell types in- cluding mast cells (MCs) and are involved in intercellular communication thanks to their complex cargo of bioactive molecules. Among them, exosomes represent nanovesicles (<150 nm) secreted from endosomal compartments upon their fusion with the plasma membrane. Through both constitutive and induced exocytosis, MCs release exosomes that deliver several molecules including mRNA/miRNA and subunits of the high-affinity IgE receptor (Fc?RI).