Ricerc@Sapienza

Malignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and medico-legal implications. Diagnosis, prognosis and therapy are often challenging and include several issues. Cytological diagnosis is frequently the first step of the diagnostic process, and although its sensitivity may be somewhat lower, diagnostic criteria should be taken into account. When effusion cytology is inconclusive for the diagnosis, tissue biopsies should be taken.

Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation. Vertebrate TnI has evolved into three isoforms encoded by three homologous genes: TNNI1 for slow skeletal muscle TnI, TNNI2 for fast skeletal muscle TnI and TNNI3 for cardiac TnI, which are expressed under muscle type-specific and developmental regulations in both the atrium and ventricle of the heart.

Late onset of fluid collection surrounding breast implants may represent a serious issue when considering the possibility of breast implant-associated anaplastic large cell lymphoma, a newly recognized type of T-cell malignancy. However, many other factors, including trauma and infections, may be implicated in the formation of non-neoplastic periprosthetic delayed effusions.

Objectives: The diagnosis of primary Sjogren’s syndrome (pSS) continues to be difficult and several patients keep
symptomatic for years with different diagnoses before confirmation of pSS. Since the IL-23-IL-17 axis is involved
in the etiopathogenesis of pSS we evaluated by immunohistochemistry and morphometric methods the presence
of IL-17 as well as IL-23 within minor salivary glands (MSG) obtained from patients with uncertain diagnosis of
pSS.
Materials and Methods: 42 patients, with symptoms attributable to pSS, and 8 patients used as a control, were

Synovial cysts are currently classified as degenerative lesions affecting the joint capsule or adjacent structures. In our study we describe the results obtained in an immunohistochemical study comprising 18 patients with synovial cysts, performed to evaluate the pathophysiological role of some inflammatory cytokines such as: IL-1β, IL-6 and TNF-α. Results showed an over-expression of TNF-α, IL-1β and IL which appears to be involved in the onset and progression of the disease.

Follicular patterned nodules are sometimes complex to be classified due to ambiguous nuclear features and/or questionable capsular or vascular invasion. In this setting, there is a poor inter-observer concordance even among expert pathologists. Raman spectroscopy was recently used to separate benign and malignant thyroid nodules based on their molecular fingerprint; anyway, some histologically proved follicular adenomas were clustered as having a characteristic profile of malignant lesions.

Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer.
Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from
2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their
findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms,
endoscopic findings, therapy, histology, and immunohistochemistry.

Splenic metastasis is uncommon and is usually associated with widespread disease. 1,2 Isolated splenic metastases from renal cancer are also rarer and are often an incidental finding. This eventuality may turn into a dangerous scenario due to a spontaneous splenic rupture leading to sudden death. 2,3 At the best of our knowledge, only few cases of metastasis from renal cell carcinoma (RCC) have been documented in the literature.

Accumulation of oxidative insults on molecular and supramolecular levels could compromise renewal potency and architecture in the aging skin.

Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given basic similarities of the fish brain to that of mammals.