Ricerc@Sapienza

In metabolic diseases, like type 2 diabetes (T2D), adipose tissue (AT) is infiltrated by macrophages and other leukocytes – which secrete many bioactive peptides leading to local and systemic low-grade chronic inflammation – and undergoes remodeling and aberrant fibrosis. Granzyme B (GrB) is a serine protease produced by some leukocytes, including cytotoxic lymphocytes and macrophages. It exerts both intracellular apoptotic function and extracellular functions, leading to tissue injury, inflammation and repair.

Postoperative complications in Crhon’s patients kn relation to
immune status — The authors report on their experience of 96 Crohn’s
disease patients observed between 1985 and 1990 and undergoing surgery
and immunologically monitored. The result obtained was better in those
patients in whom the immune response was most active.