FcepsilonRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes
Mast cells (MCs) are immune cells that act as environment resident sentinels playing a crucial role in Th2-mediated immune responses, including allergic reactions. Distinguishing features of MCs are the presence of numerous cytoplasmic granules that encapsulate a wide array of preformed bio-active molecules and the constitutive expression of the high affinity receptor of IgE (Fc epsilon RI).