RIP3 AND pMLKL promote necroptosis-induced inflammation and alter membrane permeability in intestinal epithelial cells
tBackground: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 3 (RIP3) and mixed lineage kinase domain-like protein (MLKL).Aims: The aim of this study is to examine in depth in vitro and ex vivo the contribution of necroptosis tointestinal inflammation.Methods: In vitro: we used an intestinal cell line, HCT116RIP3, produced in our laboratory and overex-pressing RIP3.