Ricerc@Sapienza

Background: Hydrogen sulphide (H2S) is enzymatically generated in various tissues and exerts many physiological effects that suggest its potential role as a regulatory mediator. H2S is involved in the regulation of vascular tone, erectile function, myocardial contractility, inflammation, neurotransmission and insulin secretion. In particular, this gaseous mediator influences the activation of cellular inflammatory processes.

Background:This crossover, randomized, double-blind study (conducted over a 32-week period) was performed todetermine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic saline onspirometry and interrupter resistance technique (Rint), and the possible side effects.Methods:Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receivehypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0.9% sodium chloride) twice a day.