Ricerc@Sapienza

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer.

This work proposes a unified framework to leveragebiological information in network propagation-based gene prior-itization algorithms. Preliminary results on breast cancer datashow significant improvements over state-of-the-art baselines,such as the prioritization of genes that are not identified aspotential candidates by interactome-based algorithms, but thatappear to be involved in/or potentially related to breast cancer,according to a functional analysis based on recent literature.