Internal Medicine

Automated classification of focal breast lesions according to S-detect: validation and role as a clinical and teaching tool

Purpose: To assess the diagnostic performance and the potential as a teaching tool of S-detect in the assessment of focal breast lesions. Methods: 61 patients (age 21–84 years) with benign breast lesions in follow-up or candidate to pathological sampling or with suspicious lesions candidate to biopsy were enrolled. The study was based on a prospective and on a retrospective phase.

Extracorporeal shockwave therapy improves functional outcomes of adhesive capsulitis of the shoulder in patients with diabetes

Adhesive capsulitis of the shoulder (ACS) is the most prevalent musculoskeletal disorder of the upper extremity (1,2) among people with diabetes. ACS is characterized by intense shoulder pain with progressive limitation of joint mobility and functional disability, negative impact on the quality of life, and increased health care costs (3).

Erratum to. usefulness of combining admission brain natriuretic peptide (BNP) plus hospital discharge bioelectrical impedance vector analysis (BIVA) in predicting 90 days cardiovascular mortality in patients with acute heart failure

In the original publication, the hydration status between survivors and non-survivors has been incorrectly mentioned in the abstract section.

The correct text should read as below:

At discharge, BIVA shows a statistically significant difference in hydration status between non survivors and survivors [respectively, hydration index (HI) 85 vs 74, p

Clinical benefits of unilateral adrenalectomy in patients with subclinical hypercortisolism due to adrenal incidentaloma. Results from a single center

Introduction: This study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders. Methods: We have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61.9 ± 8.4 years).

Toward an international consensus - integrating lipoprotein apheresis and new lipid-lowering drugs

BACKGROUND: Despite advances in pharmacotherapy of lipid disorders, many dyslipidemic patients do not attain sufficient lipid lowering to mitigate risk of atherosclerotic cardiovascular disease. Several classes of novel lipid-lowering agents are being evaluated to reduce atherosclerotic cardiovascular disease risk.

Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy

Background: Sclerostin (SC) is a monomeric glycoprotein expressed by osteocytes that affects bone formation. Recent studies have suggested a potential role for this protein in the pathophysiology of vascular diseases. The aim of the present study was to investigate SC expression in atherosclerotic plaques of patients affected by severe atherosclerotic disease who underwent carotid endarterectomy. We also evaluated possible differences in SC expression between patients with and without type 2 diabetes (T2D).

Circulating miRNA-375 levels are increased in autoantibodies-positive first-degree relatives of type 1 diabetes patients

Growing evidence suggests that microRNAs (miRNAs) play a key role in beta-cell metabolism, proliferation and apoptosis, and in immune system functions, all processes involved in the pathogenesis of type 1 diabetes.
In the context of diabetes, particular attention has been focused on miR-375, which has been studied most extensively as a putative biomarker of beta cell death. Although dysregulated miRNA profiles have been identified in type 1 diabetes patients, results are inconclusive.

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