interstitial pneumonia

PRIN 2022 - L-AIPAD: Lung-Advanced Imaging in Primary Antibody Deficiency

PRIN 2022 - L-AIPAD: Lung-Advanced Imaging in Primary Antibody Deficiency

Le deficienze primarie degli anticorpi (PAD, Primary Antibody Deficiencies) sono un gruppo di malattie caratterizzate da un compromesso dell’immunità umorale, che può colpire soggetti giovani e avere una prognosi sfavorevole. In questo contesto, il coinvolgimento polmonare — che comprende alterazioni acute e croniche sia delle vie aeree che del parenchima — rappresenta una delle principali cause di morbilità e mortalità.

Usefulness of bronchoalveolar lavage in suspect COVID-19 repeatedly negative swab test and interstitial lung disease

The diagnosis of coronavirus disease 2019 (COVID-19) relies on nasopharyngeal swab, which shows a 20–30% risk of false negativity [1]. Bronchoalveolar lavage (BAL) is reported to be useful in patients with pulmonary interstitial infiltrates on high-resolution computed tomography (HRCT). We investigated the usefulness of BAL in symptomatic patients with positive HRCT and a repeatedly negative swab test (‘grey zone’).

Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection

A pandemic outbreak of COVID-19 has been sweeping the world since December. It begins as a respiratory infection that, mainly in men with diabetes or renal impairment, evolves into a systemic disease, with SARDS, progressive endothelial cell damage, abnormal clotting and impaired cardiovascular and liver function. Some clinical trials are testing biological drugs to limit the immune system dysregulation, "cytokines storm", that causes the systemic complications of COVID-19.

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