JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer
JARID1B/KDM5B histone demethylase's mRNA is markedly over-expressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. On the other hand, its post-transcriptional regulation in cancer cells remains elusive. We performed a computational analysis of transcriptomic data from a set of 103 breast cancer patients which, along with JARID1B up-regulation, showed a strong down-regulation of two miRNA, mir-381 and mir-486, potentially targeting its mRNA.