Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells
Background: Understanding the signalling pathways involved in angiogenesis, and developing anti-angiogenic
drugs are one of the major focuses on cancer research. Herein, we assessed the effect of CPTH6, a lysine
acetyltransferase inhibitor and anti-tumoral compound, on angiogenesis-related properties of both endothelial and
cancer cells.
Methods: The in vitro effect of CPTH6 on protein acetylation and anti-angiogenic properties on endothelial and
lung cancer cells was evaluated via wound healing, trans-well invasion and migration, tube formation,