macrocycles

Botta Lab

Botta Lab

The early work of Botta group was devoted to the structural elucidation and synthesis of biological active molecules derived from plant in vivo. Since 1984, his group have been working in the field of in vitro plant tissue cultures. The general aim of the investigation was directed toward the understanding of biosynthetic pathways of the isolated metabolites and the isolation of the responsible enzymes. During this research, new plant enzymes (e.g. peroxidases) have been isolated, purified, and characterized by chemical and kinetic studies.

Spectroscopic discrimination of diastereomeric complexes involving an axially chiral receptor

The infrared multiphoton dissociation (IRMPD) spectra of electrospray ionization (ESI)-formed proton-bound complexes between the axially chiral multifunctional macrocycle MaR and d- and l-phenylalanine (PD and PL ) or d- and l-3,4-dihydroxyphenylalanine (DD and DL ) are recorded in the ?˜ =2800-3700?cm-1 region. Whereas the diastereomeric [MaR ?H?PD ]+ and [MaR ?H?PL ]+ complexes do not show any significant spectral differences, the spectrum of [MaR ?H?DD ]+ clearly diverges from that of its [MaR ?H?DL ]+ diastereomer.

Site-directed antibodies immobilization by resorc[4]arene-based immunosensors

One of the main problems in the development of immunosensors is to overcome the complexity of binding antibody to the sensor surface. Most of immobilizing methods lead to a random orientation of antibodies with a lower binding site density and immunoaffinity. In order to control the orientation of antibody immobilization, several resorc[4]arene derivatives were designed and synthesized.

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