Ricerc@Sapienza

The infrared multiphoton dissociation (IRMPD) spectra of electrospray ionization (ESI)-formed proton-bound complexes between the axially chiral multifunctional macrocycle MaR and d- and l-phenylalanine (PD and PL ) or d- and l-3,4-dihydroxyphenylalanine (DD and DL ) are recorded in the ?˜ =2800-3700?cm-1 region. Whereas the diastereomeric [MaR ?H?PD ]+ and [MaR ?H?PL ]+ complexes do not show any significant spectral differences, the spectrum of [MaR ?H?DD ]+ clearly diverges from that of its [MaR ?H?DL ]+ diastereomer.

One of the main problems in the development of immunosensors is to overcome the complexity of binding antibody to the sensor surface. Most of immobilizing methods lead to a random orientation of antibodies with a lower binding site density and immunoaffinity. In order to control the orientation of antibody immobilization, several resorc[4]arene derivatives were designed and synthesized.