Ricerc@Sapienza

We carried out a retrospective observational study of 264 HER2-positive advanced breast cancer (ABC) patients to explore the efficacy of first-line treatment with pertuzumab/trastuzumab/taxane in real-world setting. Survival data were analyzed by Kaplan Meier curves and log rank test. Median follow-up, length of pertuzumab/trastuzumab/taxane treatment and of pertuzumab, trastuzumab maintenance were 21, 4 and 15 months, respectively. The response rate was 77.3%, and the clinical benefit rate 93.6%.

An optimized system management of a commercial and industrial power system must take care of the actual operational and energetic duty of the power system distribution. A procedure based on the Arrhenius model of the Thermal Aging of Insulating Materials allows introducing the relative time coefficient (RTC) and promoting a heuristic method, as a rule of thumb, to estimate the life loss and the residual useful life for insulated power cables.

An optimized system management of a power system must take care of the actual operational and energetic duty of the power system distribution, promoting a high efficiency of power cables and avoiding their excessive gap on load and gap on lifetime. A procedure based on the Arrhenius model of the Thermal Aging of Insulating Materials allows implementing a tool to calculate the life loss and the residual useful life for insulated power cables. The paper deals with simplified models to evaluate the power cable temperature behavior considering the load current variable in the time.

Powered Two-Wheelers (PTWs) provide a suitable mode for a large portion of population in many cities due to rider’s personal convenience and the vehicle supposed easiness of manoeuvring. At the same time PTWs present serious safety issues compared to other motorized vehicles. This paper reports the main outcome of study carried out in Rome, where this mode is very popular and assesses the economic efforts to make infrastructure safer for PTWs.

When planning pedestrian facilities, comfort is a major requirement. Pedestrians decide to walk where they feel comfortable, and when they do not, they just detour from their route towards more comfortable ones. Filthy, distressed or too narrow sidewalks induce pedestrians to walk on the carriageways and this becomes extremely unsafe on routes usually walked by senior pedestrians, due to their vulnerability.